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Simply, but not completely, the eicosanoids produced when COX-1 acts on AA are protective to the stomach, kidney and other pos organs and those produced by COX-2 and LPO are inflammatory mediators. When COX-2 and LPO act on dihomo-GLA a series of anti-inflammatory or less- pos inflammatory eicosanoids are produced. The anti-inflammatory effect of dihomo-GLA , is it's ability to compete with AA for available COX-2 and LPO. The Omega-3 Story The most common source pos of omega-3 fatty acid is dietary alpha-linolenic acid (ALA). Remember this stuff is different to GLA, an omega-6 fatty acid. ALA is present in relatively small amounts in most dog food, including the premium brands. Flax seed oil is a rich source of ALA. ALA is desaturated to eicosapentaenoic acid 20:5:N3 (EPA) and this in turn is desaturated and elongated to docosahexaenoic acid 22:6:N3 (DHA). Fish oil is a rich source of EPA and DHA. EPA is a strong competitor with AA for COX-2 and LPO, also resulting in a series of anti-inflammatory or less- inflammatory eicosanoids.
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