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The presentation of problems vary with some individuals manifesting only a single change whilst others may have multiple problems. plump furries In general, metabolic disturbances are noted prior to body shape changes. The cause? The causative mechanism of these metabolic and clinical phenomena remains speculative. Several hypotheses exist. Both protease inhibitors and nucleoside analogues have been suggested to be key to the causation of these changes. However, the clinical and/or metabolic changes have plump furries been reported in persons receiving PI-containing, PI-sparing and nucleoside analogue-sparing regimens. As these changes have not been reported in untreated plump furries persons, some physicians have also speculated that these changes are a consequence of therapy. (note from Jules Levin--Don Kotler has reported observing similar body habitus changes in people with HIV as we see now in the early days of HIV prior to the use of antiretroviral therapy). Studies with a mice model of fat redistribution suggested that a high fat diet may increase the effects of PI therapy on metabolism.
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