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| interferon alfa 2b, hepatitis clinical care, uniformed services university, pathology, radiology, fat burners no ephedrine, pictures, pegulated interferon, visible human, plump lip , peg, queen fat bottomed girls , plump naked , criticism, girls with fat ass , plump and busty 2 , plump fiction , gmhc treatment issues, | Prefectural University, Okayama, 719-11 Japan Carbohydrate-responsive element-binding protein (ChREBP) is a new transcription factor that binds to the carbohydrate-responsive element of the L-type pyruvate kinase gene (L-PK). The aim of this study was to investigate the mechanism by which hbv feeding high fat diets hbv results in decreased activity of ChREBP in the liver (Yamashita, H., Takenoshita, M., Sakurai, M., Bruick, R. K., Henzel, W. J., Shillinglaw, W., Arnot, D., and Uyeda, K. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 9116-9121). We hbv cloned the rat liver ChREBP gene for use throughout this study. Acetate, octanoate, and palmitate inhibited the glucose-induced activation of L-PK transcription in ChREBP-overexpressed hepatocytes. In these hepatocytes, the cytosolic AMP concentration increased 30-fold and AMP-activated protein kinase activity was activated 2-fold. Similarly to the fatty acids, 5-amino-4-imidazolecarboxamide ribotide, a specific activator of AMP-activated protein kinase (AMPK) also inhibited the L-PK transcription activity in ChREBP-overexpressed hepatocytes. |
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| on November 27, 2001 J. Biol. Chem., peg Vol. 277, Issue 6, 3829-3835, February 8, 2002 This Article Full Text Full Text (PDF) peg All Versions of this Article: 277/6/3829 most recent M107895200v1 Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new peg issues of the journal Download to citation manager Cited by other online articles Copyright Permissions Google Scholar Articles by Kawaguchi, T. Articles by Uyeda, K. Articles citing this Article PubMed PubMed Citation Articles by Kawaguchi, T. Articles by Uyeda, K. Mechanism for Fatty Acid "Sparing" Effect on Glucose-induced Transcription REGULATION OF CARBOHYDRATE-RESPONSIVE ELEMENT-BINDING PROTEIN BY AMP-ACTIVATED PROTEIN KINASE* Takumi Kawaguchi, Kiyoshi Osatomi§, Hiromi Yamashita¶, Tsutomu Kabashima, and Kosaku Uyeda From the Department of Biochemistry, Dallas Veterans Affairs Medical Center and University of Texas Southwestern Medical Center, Dallas, Texas 75223, and the § Department of Marine Biochemistry, Nagasaki University, Nagasaki, 852 Japan and the ¶ Department of Nutritional Science, Okayama |
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